diff --git a/.github/workflows/guix-build.yml b/.github/workflows/guix-build.yml
index ba2f0a35e268..b0c7911ef394 100644
--- a/.github/workflows/guix-build.yml
+++ b/.github/workflows/guix-build.yml
@@ -9,13 +9,17 @@ on:
   pull_request_target:
     types: [labeled]
   push:
+  schedule:
+    # Run weekly at 3 AM UTC on Sunday on the default branch
+    - cron: '0 3 * * 0'
 
 jobs:
   build-image:
     runs-on: ubuntu-24.04-arm
     if: |
       (github.event_name == 'push' && (startsWith(github.ref, 'refs/tags/') || vars.RUN_GUIX_ON_ALL_PUSH == 'true')) ||
-      contains(github.event.pull_request.labels.*.name, 'guix-build')
+      contains(github.event.pull_request.labels.*.name, 'guix-build') ||
+      github.event_name == 'schedule'
     outputs:
       image-tag: ${{ steps.prepare.outputs.image-tag }}
       repo-name: ${{ steps.prepare.outputs.repo-name }}