diff --git a/Dockerfile.chainguard b/Dockerfile.chainguard
new file mode 100644
index 00000000..76b16a3c
--- /dev/null
+++ b/Dockerfile.chainguard
@@ -0,0 +1,109 @@
+FROM cgr.dev/nhs.net/node:25.2-dev AS asset_builder
+
+USER root
+WORKDIR /app
+
+COPY package.json package-lock.json rollup.config.js  ./
+COPY . .
+RUN npm ci
+RUN npm run compile
+
+
+FROM cgr.dev/nhs.net/python:3.14-dev AS python_base
+
+ENV PYTHONDONTWRITEBYTECODE=1 \
+    PYTHONUNBUFFERED=1 \
+    VIRTUAL_ENV=/app/.venv \
+    PATH="/app/.venv/bin:$PATH" \
+    USER=app
+
+RUN addgroup --gid 1000 --system ${USER} \
+    && adduser --uid 1000 --system ${USER} --ingroup ${USER}
+
+FROM python_base AS builder
+
+WORKDIR /app
+
+ENV POETRY_NO_INTERACTION=1 \
+    POETRY_VIRTUALENVS_IN_PROJECT=1 \
+    POETRY_VIRTUALENVS_CREATE=1 \
+    POETRY_CACHE_DIR=/tmp/poetry_cache
+
+COPY pyproject.toml poetry.lock ./
+RUN pip install poetry
+RUN poetry install --without dev --no-root && rm -rf $POETRY_CACHE_DIR
+
+# Chainguard/Wolfi base doesn't support Playwright's apt-based dependency installer,
+# so use a Debian slim image for the development stage where Playwright runs.
+FROM python:3.14.1-slim AS development
+
+ARG UID=1000
+ENV USER=app
+ENV APP_DIR=/app
+RUN addgroup --gid $UID --system ${USER} \
+    && adduser --uid $UID --system ${USER} --ingroup ${USER} \
+    && mkdir -p ${APP_DIR} \
+    && chown ${USER}:${USER} ${APP_DIR}
+
+ENV VIRTUAL_ENV=${APP_DIR}/.venv
+ENV PATH="$VIRTUAL_ENV/bin:$PATH"
+
+USER root
+WORKDIR ${APP_DIR}
+
+# Install system dependencies needed for Playwright
+RUN apt-get update && apt-get install -y \
+    fonts-liberation \
+    libasound2 \
+    libatk-bridge2.0-0 \
+    libatk1.0-0 \
+    libatspi2.0-0 \
+    libcups2 \
+    libdbus-1-3 \
+    libdrm2 \
+    libexpat1 \
+    libgbm1 \
+    libglib2.0-0 \
+    libgtk-3-0 \
+    libnspr4 \
+    libnss3 \
+    libx11-6 \
+    libxcomposite1 \
+    libxdamage1 \
+    libxext6 \
+    libxfixes3 \
+    libxrandr2 \
+    libxss1 \
+    libxtst6 \
+    xdg-utils \
+    && rm -rf /var/lib/apt/lists/*
+
+ENV POETRY_NO_INTERACTION=1 \
+    POETRY_VIRTUALENVS_IN_PROJECT=1 \
+    POETRY_VIRTUALENVS_CREATE=1 \
+    POETRY_CACHE_DIR=/tmp/poetry_cache \
+    PLAYWRIGHT_BROWSERS_PATH=${APP_DIR}/browsers
+
+COPY pyproject.toml poetry.lock ./
+RUN pip install poetry
+RUN poetry install --no-root && rm -rf $POETRY_CACHE_DIR
+RUN poetry run playwright install --with-deps chromium
+
+USER ${USER}
+COPY --chown=${USER}:${USER} . .
+
+FROM python_base
+
+USER ${USER}
+WORKDIR /app
+
+COPY --from=builder --chown=${USER}:${USER} ${VIRTUAL_ENV} ${VIRTUAL_ENV}
+COPY --chown=${USER}:${USER} ./lung_cancer_screening /app/lung_cancer_screening
+COPY --from=asset_builder --chown=${USER}:${USER} /app/lung_cancer_screening/assets/compiled /app/lung_cancer_screening/assets/compiled
+COPY --chown=${USER}:${USER} manage.py ./
+
+RUN python ./manage.py collectstatic --noinput
+
+EXPOSE 8000
+
+CMD ["/app/.venv/bin/gunicorn", "--bind", "0.0.0.0:8000", "lung_cancer_screening.wsgi"]
diff --git a/docker-compose.yml b/docker-compose.yml
index 2764ce11..b6375bfe 100644
--- a/docker-compose.yml
+++ b/docker-compose.yml
@@ -4,7 +4,7 @@ services:
   web:
     build:
       context: .
-      dockerfile: Dockerfile
+      dockerfile: Dockerfile.chainguard
       target: development
     command: python manage.py runserver 0.0.0.0:8000
     ports:
@@ -23,7 +23,7 @@ services:
   asset_builder:
     build:
       context: .
-      dockerfile: Dockerfile
+      dockerfile: Dockerfile.chainguard
       target: asset_builder
     command: npm run watch
     volumes: