diff --git a/packages/components/package-lock.json b/packages/components/package-lock.json
index 08e20f7140..d4b8f1e16d 100644
--- a/packages/components/package-lock.json
+++ b/packages/components/package-lock.json
@@ -1,12 +1,12 @@
 {
   "name": "@labkey/components",
-  "version": "7.7.3",
+  "version": "7.7.3-fb-urlTargetWindow503.0",
   "lockfileVersion": 3,
   "requires": true,
   "packages": {
     "": {
       "name": "@labkey/components",
-      "version": "7.7.3",
+      "version": "7.7.3-fb-urlTargetWindow503.0",
       "license": "SEE LICENSE IN LICENSE.txt",
       "dependencies": {
         "@hello-pangea/dnd": "18.0.1",
diff --git a/packages/components/package.json b/packages/components/package.json
index ae0ca2eba2..69cb3c3a95 100644
--- a/packages/components/package.json
+++ b/packages/components/package.json
@@ -1,6 +1,6 @@
 {
   "name": "@labkey/components",
-  "version": "7.7.3",
+  "version": "7.7.3-fb-urlTargetWindow503.0",
   "description": "Components, models, actions, and utility functions for LabKey applications and pages",
   "sideEffects": false,
   "files": [
diff --git a/packages/components/releaseNotes/components.md b/packages/components/releaseNotes/components.md
index f50cafc6d6..3c0c62525b 100644
--- a/packages/components/releaseNotes/components.md
+++ b/packages/components/releaseNotes/components.md
@@ -1,6 +1,10 @@
 # @labkey/components
 Components, models, actions, and utility functions for LabKey applications and pages
 
+### version TBD
+*Released*: TBD
+- GitHub Issue 503: Field editor URL option to set target window (i.e. _blank)
+
 ### version 7.7.3
 *Released*: 31 December 2025
 - [GitHub Issue #495](https://github.com/LabKey/internal-issues/issues/495)
diff --git a/packages/components/src/internal/components/domainproperties/NameAndLinkingOptions.test.tsx b/packages/components/src/internal/components/domainproperties/NameAndLinkingOptions.test.tsx
index beaafddf61..4511cec5cd 100644
--- a/packages/components/src/internal/components/domainproperties/NameAndLinkingOptions.test.tsx
+++ b/packages/components/src/internal/components/domainproperties/NameAndLinkingOptions.test.tsx
@@ -5,10 +5,12 @@ import { createFormInputId } from './utils';
 import {
     CALCULATED_CONCEPT_URI,
     DOMAIN_FIELD_DESCRIPTION,
+    DOMAIN_FIELD_FULLY_LOCKED,
     DOMAIN_FIELD_IMPORTALIASES,
     DOMAIN_FIELD_LABEL,
     DOMAIN_FIELD_ONTOLOGY_PRINCIPAL_CONCEPT,
     DOMAIN_FIELD_URL,
+    DOMAIN_FIELD_URL_TARGET,
     STORAGE_UNIQUE_ID_CONCEPT_URI,
     STRING_RANGE_URI,
 } from './constants';
@@ -29,6 +31,7 @@ const field = DomainField.create({
     label: _label,
     importAliases: _importAliases,
     URL: _URL,
+    URLTarget: '_blank',
     propertyURI: 'test',
 });
 
@@ -50,6 +53,15 @@ const calculatedField = DomainField.create({
     conceptURI: CALCULATED_CONCEPT_URI,
 });
 
+const lockedField = DomainField.create({
+    name: 'lockedField',
+    rangeURI: STRING_RANGE_URI,
+    propertyId: 3,
+    description: 'locked field desc',
+    label: 'Locked Field',
+    lockType: DOMAIN_FIELD_FULLY_LOCKED,
+});
+
 const DEFAULT_PROPS = {
     index: 1,
     domainIndex: 1,
@@ -73,21 +85,31 @@ describe('NameAndLinkingOptions', () => {
         let formField = document.querySelectorAll('#' + createFormInputId(DOMAIN_FIELD_DESCRIPTION, 1, 1));
         expect(formField.length).toEqual(1);
         expect(formField[0].textContent).toEqual(_description);
+        expect(formField[0].hasAttribute('disabled')).toEqual(false);
 
         // Label
         formField = document.querySelectorAll('#' + createFormInputId(DOMAIN_FIELD_LABEL, 1, 1));
         expect(formField.length).toEqual(1);
         expect(formField[0].getAttribute('value')).toEqual(_label);
+        expect(formField[0].hasAttribute('disabled')).toEqual(false);
 
         // Aliases
         formField = document.querySelectorAll('#' + createFormInputId(DOMAIN_FIELD_IMPORTALIASES, 1, 1));
         expect(formField.length).toEqual(1);
         expect(formField[0].getAttribute('value')).toEqual(_importAliases);
+        expect(formField[0].hasAttribute('disabled')).toEqual(false);
 
         // URL
         formField = document.querySelectorAll('#' + createFormInputId(DOMAIN_FIELD_URL, 1, 1));
         expect(formField.length).toEqual(1);
         expect(formField[0].getAttribute('value')).toEqual(_URL);
+        expect(formField[0].hasAttribute('disabled')).toEqual(false);
+
+        // URL Target
+        formField = document.querySelectorAll('#' + createFormInputId(DOMAIN_FIELD_URL_TARGET, 1, 1));
+        expect(formField.length).toEqual(1);
+        expect(formField[0].hasAttribute('checked')).toEqual(true);
+        expect(formField[0].hasAttribute('disabled')).toEqual(false);
 
         expect(container).toMatchSnapshot();
     });
@@ -119,6 +141,9 @@ describe('NameAndLinkingOptions', () => {
     test('calculated field', () => {
         render(<NameAndLinkingOptions {...DEFAULT_PROPS} field={calculatedField} />);
         expect(document.querySelectorAll('#' + createFormInputId(DOMAIN_FIELD_IMPORTALIASES, 1, 1))).toHaveLength(0);
+
+        expect(document.querySelector('#' + createFormInputId(DOMAIN_FIELD_URL, 1, 1)).getAttribute('value')).toEqual('');
+        expect(document.querySelector('#' + createFormInputId(DOMAIN_FIELD_URL_TARGET, 1, 1)).hasAttribute('checked')).toEqual(false);
     });
 
     test('hideImportAliases', () => {
@@ -132,4 +157,13 @@ describe('NameAndLinkingOptions', () => {
         );
         expect(document.querySelectorAll('#' + createFormInputId(DOMAIN_FIELD_IMPORTALIASES, 1, 1))).toHaveLength(0);
     });
+
+    test('locked field', () => {
+        render(<NameAndLinkingOptions {...DEFAULT_PROPS} field={lockedField} />);
+        expect(document.querySelector('#' + createFormInputId(DOMAIN_FIELD_LABEL, 1, 1)).hasAttribute('disabled')).toEqual(true);
+        expect(document.querySelector('#' + createFormInputId(DOMAIN_FIELD_DESCRIPTION, 1, 1)).hasAttribute('disabled')).toEqual(true);
+        expect(document.querySelector('#' + createFormInputId(DOMAIN_FIELD_IMPORTALIASES, 1, 1)).hasAttribute('disabled')).toEqual(true);
+        expect(document.querySelector('#' + createFormInputId(DOMAIN_FIELD_URL, 1, 1)).hasAttribute('disabled')).toEqual(true);
+        expect(document.querySelector('#' + createFormInputId(DOMAIN_FIELD_URL_TARGET, 1, 1)).hasAttribute('disabled')).toEqual(true);
+    });
 });
diff --git a/packages/components/src/internal/components/domainproperties/NameAndLinkingOptions.tsx b/packages/components/src/internal/components/domainproperties/NameAndLinkingOptions.tsx
index 292762ecfb..5d5c64eb16 100644
--- a/packages/components/src/internal/components/domainproperties/NameAndLinkingOptions.tsx
+++ b/packages/components/src/internal/components/domainproperties/NameAndLinkingOptions.tsx
@@ -16,6 +16,7 @@ import {
     DOMAIN_FIELD_LABEL,
     DOMAIN_FIELD_ONTOLOGY_PRINCIPAL_CONCEPT,
     DOMAIN_FIELD_URL,
+    DOMAIN_FIELD_URL_TARGET,
 } from './constants';
 import { DomainField, IDomainFormDisplayOptions } from './models';
 import { SectionHeading } from './SectionHeading';
@@ -39,6 +40,12 @@ export class NameAndLinkingOptions extends PureComponent<NameAndLinkingProps> {
         this.props?.onChange(id, value);
     };
 
+    handleURLTargetChange = (evt: any): void => {
+        const id = evt.target.id;
+        const isChecked = evt.target.checked;
+        this.onChange(id, isChecked ? '_blank' : null);
+    };
+
     getImportAliasHelpText = (): ReactNode => {
         return (
             <>
@@ -120,6 +127,16 @@ export class NameAndLinkingOptions extends PureComponent<NameAndLinkingProps> {
                             )}
                     </div>
                     <div className="col-xs-4">
+                        {!appPropertiesOnly &&
+                            hasModule(ONTOLOGY_MODULE_NAME) &&
+                            !field.isUniqueIdField() &&
+                            !field.isCalculatedField() && (
+                                <OntologyConceptAnnotation
+                                    field={field}
+                                    id={createFormInputId(DOMAIN_FIELD_ONTOLOGY_PRINCIPAL_CONCEPT, domainIndex, index)}
+                                    onChange={this.onChange}
+                                />
+                            )}
                         <div className="domain-field-label">
                             <DomainFieldLabel label="URL" helpTipBody={this.getURLHelpText()} />
                         </div>
@@ -132,16 +149,19 @@ export class NameAndLinkingOptions extends PureComponent<NameAndLinkingProps> {
                             onChange={this.handleChange}
                             disabled={isFieldFullyLocked(field.lockType)}
                         />
-                        {!appPropertiesOnly &&
-                            hasModule(ONTOLOGY_MODULE_NAME) &&
-                            !field.isUniqueIdField() &&
-                            !field.isCalculatedField() && (
-                                <OntologyConceptAnnotation
-                                    id={createFormInputId(DOMAIN_FIELD_ONTOLOGY_PRINCIPAL_CONCEPT, domainIndex, index)}
-                                    field={field}
-                                    onChange={this.onChange}
-                                />
-                            )}
+                        {/*GitHub Issue 503: Field editor URL option to set target window (i.e. _blank)*/}
+                        <div className="domain-text-options-col">
+                            <input
+                                type="checkbox"
+                                id={createFormInputId(DOMAIN_FIELD_URL_TARGET, domainIndex, index)}
+                                name={createFormInputName(DOMAIN_FIELD_URL_TARGET)}
+                                className="form-control domain-text-option-urltarget"
+                                checked={field.URLTarget === '_blank'}
+                                onChange={this.handleURLTargetChange}
+                                disabled={isFieldFullyLocked(field.lockType)}
+                            />
+                            <span>Open links in a new tab</span>
+                        </div>
                     </div>
                 </div>
             </div>
diff --git a/packages/components/src/internal/components/domainproperties/__snapshots__/NameAndLinkingOptions.test.tsx.snap b/packages/components/src/internal/components/domainproperties/__snapshots__/NameAndLinkingOptions.test.tsx.snap
index 4ac4b5d759..6d6ea29fa3 100644
--- a/packages/components/src/internal/components/domainproperties/__snapshots__/NameAndLinkingOptions.test.tsx.snap
+++ b/packages/components/src/internal/components/domainproperties/__snapshots__/NameAndLinkingOptions.test.tsx.snap
@@ -110,6 +110,20 @@ exports[`NameAndLinkingOptions Name and Linking options 1`] = `
           type="text"
           value="This is a URL"
         />
+        <div
+          class="domain-text-options-col"
+        >
+          <input
+            checked=""
+            class="form-control domain-text-option-urltarget"
+            id="domainpropertiesrow-URLTarget-1-1"
+            name="domainpropertiesrow-URLTarget"
+            type="checkbox"
+          />
+          <span>
+            Open links in a new tab
+          </span>
+        </div>
       </div>
     </div>
   </div>
diff --git a/packages/components/src/internal/components/domainproperties/constants.ts b/packages/components/src/internal/components/domainproperties/constants.ts
index 7525f0dce1..80aba4c72c 100644
--- a/packages/components/src/internal/components/domainproperties/constants.ts
+++ b/packages/components/src/internal/components/domainproperties/constants.ts
@@ -27,6 +27,7 @@ export const DOMAIN_FIELD_DESCRIPTION = 'description';
 export const DOMAIN_FIELD_LABEL = 'label';
 export const DOMAIN_FIELD_IMPORTALIASES = 'importAliases';
 export const DOMAIN_FIELD_URL = 'URL';
+export const DOMAIN_FIELD_URL_TARGET = 'URLTarget';
 export const DOMAIN_FIELD_LOOKUP_CONTAINER = 'lookupContainer';
 export const DOMAIN_FIELD_LOOKUP_QUERY = 'lookupQueryValue';
 export const DOMAIN_FIELD_LOOKUP_SCHEMA = 'lookupSchema';
diff --git a/packages/components/src/internal/components/domainproperties/models.test.ts b/packages/components/src/internal/components/domainproperties/models.test.ts
index 1e4adbe6e1..1b5e02acdc 100644
--- a/packages/components/src/internal/components/domainproperties/models.test.ts
+++ b/packages/components/src/internal/components/domainproperties/models.test.ts
@@ -122,6 +122,7 @@ const gridDataAppPropsOnlyConst = [
         scale: 4000,
         name: 'a',
         URL: '',
+        URLTarget: '',
         conceptURI: '',
         rangeURI: 'http://www.w3.org/2001/XMLSchema#int',
         PHI: '',
@@ -188,6 +189,7 @@ const nameCol = new GridColumn({
 const gridColumnsConst = [
     selectionCol,
     nameCol,
+    { index: 'URLTarget', caption: 'URL Target', sortable: true },
     { index: 'URL', caption: 'URL', sortable: true },
     { index: 'PHI', caption: 'PHI', sortable: true },
     { index: 'rangeURI', caption: 'Range URI', sortable: true },
@@ -1490,6 +1492,13 @@ describe('resolveBaseProperties', () => {
             DOMAIN_FIELD_PARTIALLY_LOCKED
         );
     });
+
+    test('URLTarget', () => {
+        expect(DomainField.resolveBaseProperties({}).URLTarget).toBeUndefined();
+        expect(DomainField.resolveBaseProperties({ URLTarget: '_self' }).URLTarget).toBeUndefined();
+        expect(DomainField.resolveBaseProperties({ urltarget: '_self' }).URLTarget).toBe('_self');
+        expect(DomainField.resolveBaseProperties({ urltarget: '_blank' }).URLTarget).toBe('_blank');
+    });
 });
 
 describe('resolveLookupQueryValue', () => {
diff --git a/packages/components/src/internal/components/domainproperties/models.tsx b/packages/components/src/internal/components/domainproperties/models.tsx
index 50326689f3..c199713296 100644
--- a/packages/components/src/internal/components/domainproperties/models.tsx
+++ b/packages/components/src/internal/components/domainproperties/models.tsx
@@ -549,7 +549,14 @@ export class DomainDesign
         if (!showFilterCriteria) delete columns.filterCriteria;
 
         const unsortedColumns = List(
-            Object.keys(columns).map(key => ({ index: key, caption: camelCaseToTitleCase(key), sortable: true }))
+            Object.keys(columns).map(key => {
+                let caption = camelCaseToTitleCase(key);
+                // special case for url and urltarget
+                if (key.toLowerCase() === 'url') caption = 'URL';
+                if (key.toLowerCase() === 'urltarget') caption = 'URL Target';
+
+                return { index: key, caption, sortable: true };
+            })
         );
         return specialCols.concat(unsortedColumns.sort(reorderSummaryColumns)).toList();
     }
@@ -914,6 +921,7 @@ export interface IDomainField {
     uniqueConstraint?: boolean;
     updatedField: boolean;
     URL?: string;
+    URLTarget?: string;
     visible: boolean;
 }
 
@@ -985,6 +993,7 @@ export class DomainField
         required: false,
         scale: MAX_TEXT_LENGTH,
         URL: undefined,
+        URLTarget: undefined,
         shownInDetailsView: true,
         shownInInsertView: true,
         shownInUpdateView: true,
@@ -1047,6 +1056,7 @@ export class DomainField
     declare scale?: number;
     declare scannable?: boolean;
     declare URL?: string;
+    declare URLTarget?: string;
     declare shownInDetailsView?: boolean;
     declare shownInInsertView?: boolean;
     declare shownInUpdateView?: boolean;
@@ -1190,6 +1200,11 @@ export class DomainField
             field.rangeURI = raw.rangeURI;
         }
 
+        // handle URLTarget prop casing mismatch
+        if (raw['urltarget']) {
+            field.URLTarget = raw['urltarget'];
+        }
+
         return field;
     }
 
@@ -1215,6 +1230,10 @@ export class DomainField
                 json.url = json.URL;
                 delete json.URL;
             }
+            if (json.URLTarget !== undefined) {
+                json.urltarget = json.URLTarget; // note casing because of GWTPropertyDescriptor behavior on server side
+                delete json.URLTarget;
+            }
             if (json.PHI !== undefined) {
                 json.phi = json.PHI;
                 delete json.PHI;
diff --git a/packages/components/src/internal/components/domainproperties/propertiesUtil.ts b/packages/components/src/internal/components/domainproperties/propertiesUtil.ts
index 1858fb1dda..9efbce3b2a 100644
--- a/packages/components/src/internal/components/domainproperties/propertiesUtil.ts
+++ b/packages/components/src/internal/components/domainproperties/propertiesUtil.ts
@@ -147,6 +147,7 @@ export function reorderSummaryColumns(a: DomainPropertiesGridColumn, b: DomainPr
         'label',
         'importAliases',
         'url',
+        'urltarget',
         'conditionalFormats',
         'propertyValidators',
         'valueExpression',
diff --git a/packages/components/src/theme/domainproperties.scss b/packages/components/src/theme/domainproperties.scss
index 17bf43d2c0..d3633a010e 100644
--- a/packages/components/src/theme/domainproperties.scss
+++ b/packages/components/src/theme/domainproperties.scss
@@ -359,7 +359,7 @@
   margin: 6px 20px 0 0 !important;
 }
 
-.domain-text-option-scannable {
+.domain-text-option-scannable, .domain-text-option-urltarget {
     display: inline;
 }